فوق دکترا درجراحی کلیه ومجاری ادرار ازدانشکده پزشکی دانشگاه تهران و عضو انجمن ارولوژی ایران
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كاربر میهمان خوش آمدید
Sat 16 Jul 2011

In The Name Of God

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The Books  That Authored And Translated by

Mohammad Hezarkhani

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ارسال شده توسط دکتر محمد هزارخانی در ساعت 3:32 بعد از ظهر
Tue 30 Sep 2014

 هیرسوتنون،عصاره گیاه توسکا(نواحی مرطوب مانند مازندران)تکثیر سلولهای سرطانی پروستات را مهار می کند.

Edited by:Mohammad  Hezarkhani  MD,Urologist

Board-Certified of Urology,Tehran  University ,The Member  of  Iranian  Urological  Association

Madaen Hospital  Tehran Iran

Tehranclinic  Hospital Tehran Iran

Mohammad.hezarkhani@yahoo.com

www.Hezarkhani.blogfa.com  hosted in Washington DC, United States

September,30. 2014

Alder is the common name of a genus of flowering plants (Alnus) belonging to the birch family Betulaceae. The genus comprises about 30 species of monoecious trees and shrubs, a few reaching a large size, distributed throughout the north temperate zone with a few species extending into Central America and the northern Ande.

Alders are deciduous, and the leaves are alternate, simple, and serrated. The flowers are catkins with elongate male catkins on the same plant as shorter female catkins, often before leaves appear; they are mainly wind-pollinated, but also visited by bees to a small extent. These trees differ from the birches (Betula, the other genus in the family) in that the female catkins are woody and do not disintegrate at maturity, opening to release the seeds in a similar manner to many conifer cones.

The largest species are red alder (A. rubra) on the west coast of North America, and black alder (A. glutinosa), native to most of Europe and widely introduced elsewhere, both reaching over 30 m. By contrast, the widespread Alnus viridis (green alder) is rarely more than a 5-m-tall shrub.

Sequences of nuclear ribosomal DNA ITS region were used to estimate phylogenetic relationships of Alnus. Researchers recognize three major clades in Alnus, including subgenera Alnobetula, Clethropsis, and Alnus; subgenus Alnobetula is sister to subgenera Clethropsis and Alnus. The eastern Asian subgenus or section Cremastogyne is embedded in the subgenus Alnus clade. Alnus nepalensis is part of subgenus Alnus, not subgenus Clethropsis. Alnus maritima is part of subgenus Clethropsis (excl. A. nepalensis).

 Long and short branching pattern, sessile winter bud, and 2‐yr phenology are plesiomorphies in Alnus, while 1‐yr floral phenology and fall blooming are derived features. The simple axillary female inflorescence has evolved more than once in Alnus. Central and South American species of Alnus are derived from migrants from eastern Asia via the Bering land bridge and western North America. In subgenus Clethropsis, A. formosana of eastern Asia is more closely related to eastern North American species than to the other Asian species, A. nitida. The low sequence divergence within both the A. incana and A.

viridis species complexes indicates their recent history of diversification in the circumpolar areas. Although specific compounds found in some East Asian traditional medicines have been shown to exhibit bioactive properties, their molecular mechanisms of action remain elusive. The bark of the Alnus species has been used for the treatment of various pathological conditions including hemorrhage, alcoholism, fever, diarrhea, skin diseases, inflammation, and cancer in East Asia for centuries.

In this study, researchers show that hirsutenone, a bioactive compound in Alnus japonica, exhibits anti-cancer effects against prostate cancer through a direct physical inhibition of Akt1/2. Hirsutenone suppressed anchorage-dependent and independent cell growth of PC3 and LNCaP human prostate cancer cells. Annexin V and Propidium iodide (PI) staining results demonstrated that hirsutenone strongly induces apoptotic cell death in both PC3 and LNCaP cells.

Furthermore, treatment of hirsutenone attenuated phosphorylation of mammalian target of rapamycin (mTOR), a downstream substrate of Akt, without affecting Akt phosphorylation. Kinase and pull-down assay results clearly show that hirsutenone inhibits Akt1 and 2 by direct binding in an adenosine triphosphate (ATP)-noncompetitive manner in vitro and ex vivo.

The results show that hirsutenone suppresses human prostate cancer by targeting Akt1 and 2 as a key component to explain for anti-cancer activity of Alnus species.

References:

1-Mol Carcinog. 2014 Sep 11. doi: 10.1002/mc.22211.

Hirsutenone in Alnus extract inhibits akt activity and suppresses prostate cancer cell proliferation.

Kang S1, Kim JE, Li Y, Jung SK, Song NR, Thimmegowda NR, Kim BY, Lee HJ, Bode AM, Dong Z, Lee KW.

2-Phylogenetics and Biogeography of Alnus (Betulaceae) Inferred from Sequences of Nuclear Ribosomal DNA ITS Region

Zhiduan Chen, Jianhua Li/International Journal of Plant Sciences, Vol. 165, No. 2 (March 2004), pp. 325-335

3- Alder Wikipedia, the free encyclopedia 8 September 2014

ارسال شده توسط دکتر محمد هزارخانی در ساعت 11:36 بعد از ظهر |
Tue 30 Sep 2014
 

1 Sexually transmitted infections and prostate cancer risk: A systematic review and meta-analysis Cancer Epidemiology, September 30, 2014    

 

2 Adenocarcinoma of the prostate with Gleason pattern 5 on core biopsy: Frequency of diagnosis, morphologic subpatterns, and relation to pattern distribution based on the modified Gleason grading system Human Pathology, September 30, 2014

 

3 Prognostic impact of definitive local therapy of the primary tumor in men with metastatic prostate cancer at diagnosis: A population-based, propensity score analysis Cancer Epidemiology, September 30, 2014   

 

4 Increased nuclear factor erythroid 2-related factor 2 expression predicts worse prognosis of prostate cancer patients treated with radical prostatectomy Human Pathology, September 30, 2014

 

5 Five year prostate-specific antigen outcomes after caesium prostate brachytherapy Clinical Oncology, September 30, 2014    

 

6 Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer Molecular Cancer Research, September 30, 2014    

 

7 Androgen receptor polymorphism-dependent variation in prostate-specific antigen concentrations of European men Cancer Epidemiology, Biomarkers & Prevention, September 30, 2014    

 

8 Hirsutenone in Alnus extract inhibits akt activity and suppresses prostate cancer cell proliferation Molecular Carcinogenesis, September 30, 2014   

 

9 Circulating tumor cell telomerase activity as a prognostic marker for overall survival in SWOG 0421: A phase 3 metastatic castration resistant prostate cancer trial International Journal of Cancer, September 30, 2014   

 

10 RSK promotes prostate cancer progression in bone through ING3, CKAP2 and PTK6-mediated cell survival Molecular Cancer Research, September 30, 2014    

 

11 Improved volume selective 1H MR spectroscopic imaging of the prostate with gradient offset independent adiabaticity pulses at 3 tesla Magnetic Resonance in Medicine, September 30, 2014   

 

12 Relationship between seminal plasma levels of anandamide congeners palmitoylethanolamide and oleoylethanolamide and semen quality Fertility and Sterility, September 30, 2014

 

13 Development of a simplified method of human semen storage for the testing of sperm DNA fragmentation using the Halosperm G2 test kit Fertility and Sterility, September 30, 2014  

 

14 Pelvic-floor muscle rehabilitation in erectile dysfunction and premature ejaculation Physical Therapy, September 30, 2014   

 

15 Expression profile of epithelial-mesenchymal transition markers in non-muscle-invasive urothelial carcinoma of the bladder: Correlation with intravesical recurrence following transurethral resection Urologic Oncology: Seminars and Original Investigations, September 30, 2014    

 

16 Rare cause of macroscopic hematuria in a pediatric patient: Nephrogenic adenoma of the bladder Pediatrics International, September 30, 2014

 

17 Significance of perivesical lymph nodes in radical cystectomy for bladder cancer Urologic Oncology: Seminars and Original Investigations, September 30, 2014    

 

18 Clinical significance of tumor-derived IL-1β and IL-18 in localized renal cell carcinoma: Associations with recurrence and survival Urologic Oncology: Seminars and Original Investigations, September 30, 2014    

 

19 A comparison of case volumes among urologic surgeons identified on an industry-sponsored website to an all provider peer group Urologic Oncology: Seminars and Original Investigations, September 30, 2014    

 

20 The preoperative prognostic nutritional index is an independent predictor of survival in patients with renal cell carcinoma Urologic Oncology: Seminars and Original Investigations, September 30, 2014   

 

 

 

 

1 Coffee and caffeine intake and risk of endometriosis: a meta-analysis European Journal of Nutrition, September 30, 2014    

 

2 Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition Cancer Epidemiology, September 30, 2014    

 

3 Variation in outcomes in trials reporting effects of diet and lifestyle based intervention on pregnancy outcomes: A systematic review Pregnancy Hypertension, September 30, 2014

 

4 The association between maternal age and depression Full Text Journal of Obstetrics and Gynaecology Canada, September 30, 2014    

 

5 Better diet quality before pregnancy is associated with reduced risk of gastroschisis in Hispanic women The Journal of Nutrition, September 30, 2014   

 

6 Utility of ultrasound in the diagnosis of polycystic ovary syndrome in adolescents Fertility and Sterility, September 30, 2014   

 

7 Preventing pre-eclampsia - Are dietary factors the key? Full Text BMC Medicine, September 30, 2014

 

8 Pain in diagnostic hysteroscopy: A multivariate analysis after a randomized, controlled trial Fertility and Sterility, September 30, 2014    

 

9 Acupuncture for chronic pelvic inflammatory disease: A qualitative study of patients’ insistence on treatment Full Text BMC Complementary and Alternative Medicine, September 30, 2014    

 

10 Pregnancy and levels of depression and anxiety: A prospective cohort study of Australian women Australian and New Zealand Journal of Psychiatry, September 30, 2014    

 

11 Neuroimaging features and predictors of outcome in eclamptic encephalopathy: A prospective observational study American Journal of Neuroradiology, September 30, 2014    

 

12 Breast cancer in young women: Have the prognostic implications of breast cancer subtypes changed over time? Breast Cancer Research and Treatment, September 30, 2014    

 

13 Association of TP53 PIN3 polymorphism with breast cancer in Moroccan population Tumor Biology, September 30, 2014   

 

14 Clinical validation of embryo culture and selection by morphokinetic analysis: A randomized, controlled trial of the EmbryoScope Fertility and Sterility, September 30, 2014    

 

15 Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform Fertility and Sterility, September 30, 2014    

 

16 Blastocyst euploidy and implantation rates in a young (

 

17 Association of CDKN2B-AS and WNT4 genetic polymorphisms in Korean patients with endometriosis Fertility and Sterility, September 30, 2014  

 

18 Female cystic fibrosis mutation carriers and assisted reproductive technology: Does carrier status affect reproductive outcomes? Fertility and Sterility, September 30, 2014    

 

19 Whether sperm deoxyribonucleic acid fragmentation has an effect on pregnancy and miscarriage after in vitro fertilization/intracytoplasmic sperm injection: A systematic review and meta-analysis Fertility and Sterility, September 30, 2014    

 

20 Posthumous reproduction with surplus in vitro fertilization embryos: A study exploring users' choices Fertility and Sterility, September 30, 2014   

ارسال شده توسط دکتر محمد هزارخانی در ساعت 10:2 بعد از ظهر |
Mon 29 Sep 2014

 

1 Prostate bed radiation therapy: The utility of ultrasound volumetric imaging of the bladder Clinical Oncology, September 29, 2014    

 

2 Positive and negative mood in men with advanced prostate cancer undergoing androgen deprivation therapy: Considering the role of social support and stress Psycho-Oncology, September 29, 2014    

 

3 Patient-reported outcomes and health-related quality of life in prostate cancer treated with a single fraction of high dose rate brachytherapy combined with hypofractionated external beam radiotherapy Clinical Oncology, September 29, 2014    

 

4 In patients with a previous negative prostate biopsy and a suspicious lesion on MRI, is a 12-core biopsy still necessary in addition to a targeted biopsy? BJU International, September 29, 2014  

 

5 Myeloid derived suppressor and dendritic cell subsets are related to clinical outcome in prostate cancer patients treated with prostate GVAX and ipilimumab Full Text Journal for ImmunoTherapy of Cancer, September 29, 2014  

 

6 Expression of E6AP and PML predicts for prostate cancer progression and cancer specific death Annals of Oncology, September 29, 2014

 

7 The alteration of inflammatory markers and apoptosis on chronic prostatitis induced by estrogen and androgen International Urology and Nephrology, September 29, 2014  

 

8 Role of radical prostatectomy in clinically non-organ-confined prostate cancer Current Urology Reports, September 29, 2014  

 

9 Impact of pelvic osteotomy on the incidence of inguinal hernias in classic bladder exstrophy Journal of Pediatric Surgery, September 29, 2014

 

10 Time lines in the management of adrenal crisis – targets, limits and reality Clinical Endocrinology, September 29, 2014  

 

11 Induction of integrin alpha2 in a highly bone metastatic human prostate cancer cell line: roles of RANKL and AR under three-dimensional suspension culture Molecular Cancer, September 29, 2014

 

12 High body mass index has a deleterious effect on semen parameters except morphology: Results from a large cohort study Fertility and Sterility, September 29, 2014   

 

13 Polymorphisms of NRF2 and NRF2 target genes in urinary bladder cancer patients Journal of Cancer Research & Clinical Oncology, September 29, 2014   

 

14 Metabolic abnormalities and polymorphisms of the vitamin D receptor (VDR) and ZNF365 genes in children with urolithiasis Urolithiasis, September 29, 2014   

 

15 Caval thrombus in conjunction with renal tumors: Indication for surgery and technical details Current Urology Reports, September 29, 2014   

 

16 68Ga DOTANOC PET/CT aiding in the diagnosis of Von Hippel-Lindau syndrome by detecting cerebellar hemangioblastoma and adrenal pheochromocytoma Clinical Nuclear Medicine , September 29, 2014    

 

17 Aldosterone-cortisol imbalance immediately after fontan operation with implications for abnormal fluid homeostasis The American Journal of Cardiology, September 29, 2014  

 

18 Optimizing cryopreservation of human spermatogonial stem cells: Comparing the effectiveness of testicular tissue and single cell suspension cryopreservation Fertility and Sterility, September 29, 2014  

 

19 Acrosome reaction is impaired in spermatozoa of obese men: A preliminary study Fertility and Sterility, September 29, 2014

 

20 Human papillomavirus-related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection International Journal of Urology, September 29, 2014

ارسال شده توسط دکتر محمد هزارخانی در ساعت 2:43 بعد از ظهر |
Sun 28 Sep 2014

Case Reports in Urology

Metastatic Prostate Adenocarcinoma Posing as Urothelial Carcinoma of the Right Ureter: A Case Report and Literature Review

Tian-bao Huang,1,2 Yang Yan,1 Huan Liu,1,2 Jian-ping Che,1,2 Guang-chun Wang,1,2 Min Liu,1,2 Jun-hua Zheng,1,2 and Xu-dong Yao1,2/1Department of Urology, Shanghai Tenth People’s Hospital, Tongji University, 301 Yanchang Road, Shanghai 200072, China/2Department of First Clinical Medical College, Nanjing Medical University, Nanjing, Jiangsu 210029, China/13 August 2014

 

This is a case report of a 67-year-old patient with distant metastasis of prostate cancer to the right ureter which caused hydronephrosis. At the beginning, both of the cytology of the morning urine and imaging findings were consistent with urothelial carcinoma. Nephroureterectomy was subsequently performed. Interestingly, the pathological examination of the excised ureter revealed that the malignancy was derived from the prostate. No skeletal metastasis was detected. However, after four months of follow-up, several abnormal signal shadows were reported in skeletal scintigraphy and the prostate specific antigen (PSA) was gradually increasing. We present such a case for its unique presentation. A review of the literature is also provided.

SOURCE: Volume 2014 (2014), Article ID 230852, 5 pages

http://dx.doi.org/10.1155/2014/230852

ارسال شده توسط دکتر محمد هزارخانی در ساعت 11:20 بعد از ظهر |
Sat 27 Sep 2014


Doses of at least 25 mcg linked to decreased nocturnal voids, increased time to first void

WEDNESDAY, Sept. 24, 2014 (HealthDay News) -- Desmopressin offers a modest benefit for treating nocturia in generally healthy adults, according to a systematic review published in the September issue of The Journal of Urology.

Mark H. Ebell, M.D., from the University of Georgia in Athens, and colleagues conducted a systematic literature review to examine the benefits and harms of desmopressin as treatment for nocturia. A total of 10 articles involving 2,191 patients met the inclusion criteria of parallel group design, randomized, controlled trials with information on one or more benefit or harm of desmopressin in patients with nocturia. The studies were generally of high quality, although four studies were at high risk for bias.

The researchers found that there were decreases in nocturnal voids and increased time to first void with desmopressin doses of 25 mcg or greater. Compared with placebo, a 100-mcg dose provided just over one hour of additional sleep before the first void and 0.72 fewer voids per night. There was no significantly increased benefit with higher doses. The most common adverse effects were hyponatremia (risk ratio, 5.1) and headache (risk ratio, 4.3), while serious adverse effects were rare.

ارسال شده توسط دکتر محمد هزارخانی در ساعت 8:8 بعد از ظهر |
Sat 27 Sep 2014


Young women should be screened yearly for the sexually transmitted disease, experts say

THURSDAY, Sept. 25, 2014 (HealthDay News) -- An estimated 1.8 million Americans aged 14 to 39 are infected with Chlamydia trachomatis, and many don't know it, according to research published in the Sept. 26 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

The CDC report was based on statistics from the 2007 to 2012 National Health and Nutrition Examination Survey. Rates of infection are highest among young women. An estimated 4.7 percent of women aged 14 to 24 were infected with the disease in 2012.

In addition, the researchers found that infection rates were highest among black women aged 14 to 24 -- at 13.5 percent. Among Mexican-American women, the rate of infection was 4.5 percent. And among white women, it was 1.8 percent. The overall prevalence of chlamydia among those aged 14 to 39 has remained virtually unchanged for nearly a decade. From 2007 to 2008, the infection rate was 1.6 percent; from 2009 to 2010, it was 1.7 percent; and from 2011 to 2012, it was 1.9 percent.

"Chlamydia is common, and it's especially common in young women. Most young women who are infected don't know they have it," study author Elizabeth Torrone, Ph.D., an epidemiologist with the CDC's division of STD prevention, told HealthDay. "This report really underscores the need for young women to be screened for chlamydia annually."

ارسال شده توسط دکتر محمد هزارخانی در ساعت 8:3 بعد از ظهر |
Sat 27 Sep 2014


Findings based on large retrospective study of patients with type 2 diabetes

FRIDAY, Sept. 26, 2014 (HealthDay News) -- Higher levels of high-density lipoprotein cholesterol (HDL-C) are associated with a decreased risk of cancer among individuals with type 2 diabetes, according to a study published online Sept. 11 in Diabetes Care.

Wenhui Zhao, M.D., from the Pennington Biomedical Research Center in Baton Rouge, La., and colleagues retrospectively analyzed data from a cohort of 14,169 men and 23,176 women with type 2 diabetes. Patients were categorized by HDL-C level to assess cancer risk.

The researchers found that over 6.4 years of follow-up, 3,711 patients with type 2 diabetes were diagnosed with cancer. There was a significant inverse association between HDL-C and the risk of cancer among both men and women. By HDL-C level at baseline, the multivariable-adjusted hazard ratios of cancer were 1.00 for <30; 0.87 at 30 to 39.9; 0.95 at 40 to 49.9; 1.01 at 50 to 59.9; 0.61 at 60 to 69.9; 0.45 at 70 to 79.9; and 0.37 at ≥80 mg/dL in men (Ptrend = 0.027). For women, the corresponding hazard ratios were 1.00, 0.98, 0.88, 0.85, 0.84, 0.86, and 0.84 (Ptrend = 0.025). The association remained when stratified by race, body mass index, smoking status, or medication use; however, the inverse association was substantially weakened after excluding patients who died of or were diagnosed with cancer during the first two years of follow-up.

"The study suggests an inverse association of HDL-C with cancer risk among men and women with type 2 diabetes, whereas the effect of HDL-C was partially mediated by reverse causation," the authors write.

ارسال شده توسط دکتر محمد هزارخانی در ساعت 8:0 بعد از ظهر |
Fri 26 Sep 2014

 

Sep.26,2014

1 The impact of PSA and digital rectal examination on the risk of prostate cancer specific mortality in men with a PSA level <2.5 ng/ml Cancer Epidemiology, September 26, 2014   

 

2 Impact of adjuvant radiotherapy on survival of patients with node-positive prostate cancer Journal of Clinical Oncology, September 26, 2014    

 

3 The influence of prior abiraterone treatment on the clinical activity of docetaxel in men with metastatic castration-resistant prostate cancer Full Text European Urology, September 26, 2014

 

4 Assessment of the bone scan index in a randomized placebo-controlled trial of tasquinimod in men with metastatic castration-resistant prostate cancer (mCRPC) Urologic Oncology: Seminars and Original Investigations, September 26, 2014

 

5 Effectiveness and safety of cabazitaxel plus prednisolone chemotherapy for metastatic castration-resistant prostatic carcinoma: Data on Korean patients obtained by the cabazitaxel compassionate-use program Cancer Chemotherapy and Pharmacology, September 26, 2014  

 

6 Cancer incidence in a cohort with high fish consumption Cancer Causes and Control, September 26, 2014    

 

7 Hormone and radiotherapy versus hormone or radiotherapy alone for non-metastatic prostate cancer: A systematic review with meta-analyses Clinical Oncology, September 26, 2014

 

8 Prevalence and prognostic significance of TMPRSS2-ERG gene fusion in lymph node positive prostate cancers The Prostate, September 26, 2014  

 

9 Oncologic and quality-of-life outcomes with wide resection in robot-assisted laparoscopic radical prostatectomy Urologic Oncology: Seminars and Original Investigations, September 26, 2014    

 

10 Rating general practitioner consultation performance in cancer care: does the specialty of assessors matter? A simulated patient study Full Text BMC Family Practice, September 26, 2014

 

11 Impact of race in a predominantly African-American population of patients with low/intermediate risk prostate cancer undergoing radical prostatectomy within an equal access care institution International Urology and Nephrology, September 26, 2014   

 

12 Outcome of vesicourethral anastomosis after robot-assisted laparoscopic radical prostatectomy: A 6-year experience in Taiwan Journal of the Formosan Medical Association, September 26, 2014    

 

13 Multimodal imaging for improved diagnosis and treatment of cancers Cancer, September 26, 2014   

 

14 Incidence, characteristics, treatment strategies, and oncologic outcomes of synchronous bilateral upper tract urothelial carcinoma in the Chinese population Urologic Oncology: Seminars and Original Investigations, September 26, 2014    

 

15 Does percutaneous nephrolithotomy and its outcomes have an impact on renal function? Quantitative analysis using SPECT-CT DMSA Urolithiasis, September 26, 2014    

 

16 Surveillance of nonmelanoma skin cancer incidence rates in kidney transplant recipients in Ireland Transplantation, September 26, 2014  

 

17 The effects of liraglutide on male fertility: A case report Reproductive BioMedicine Online, September 26, 2014

 

18 Comprehensive meiotic segregation analysis of a 4-breakpoint t(1;3;6) complex chromosome rearrangement using single sperm array comparative genomic hybridization and FISH Reproductive BioMedicine Online, September 26, 2014    

 

19 Pregnancy outcome according to male diagnosis after ICSI with non-ejaculated sperm compared with ejaculated sperm controls Reproductive BioMedicine Online, September 26, 2014

  

20Vitamin E, selenium supplements unlikely to affect age-related cataracts in men

21Professional recommendations against routine prostate cancer screening have little effect

22Blood test could identify when cancer treatment has become detrimental

23Finding new genetic links to prostate cancer

24Study identifies when and how much various prostate cancer treatments will impact urinary and sexual functioning

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1 Dietary folate and reproductive success among women undergoing assisted reproduction Obstetrics and Gynecology, September 26, 2014    

 

2 Use of medical, surgical and complementary treatments among women with fibroids European Journal of Obstetrics & Gynecology and Reproductive Biology, September 26, 2014   

 

3 Maternal body mass index influences umbilical artery doppler velocimetry in physiologic pregnancies Prenatal Diagnosis, September 26, 2014   

 

4 Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: A randomized controlled trial Obstetrics and Gynecology, September 26, 2014    

 

5 Effects of a contraceptive containing drospirenone and ethinylestradiol on blood pressure, metabolic profile and neurohumoral axis in hypertensive women at reproductive age European Journal of Obstetrics & Gynecology and Reproductive Biology, September 26, 2014    

 

6 Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling Carcinogenesis, September 26, 2014   

 

7 Psychosocial influences on glycemic control in women with pre-existing diabetes preparing for pregnancy Canadian Journal of Diabetes, September 26, 2014    

 

8 Molecular diagnostics and therapeutics for ectopic pregnancy Molecular Human Reproduction, September 26, 2014   

 

9 Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study Genes and Immunity, September 26, 2014   

 

10 Discontinuation of antipsychotic medication in pregnancy: A cohort study Schizophrenia Research, September 26, 2014   

 

11 Timing of pregnancy in obese women after bariatric surgery Pregnancy Hypertension, September 26, 2014   

 

12 Primary results of rose/trio-12, a randomized placebo-controlled phase iii trial evaluating the addition of ramucirumab to first-line docetaxel chemotherapy in metastatic breast cancer Journal of Clinical Oncology, September 26, 2014    

 

13 Intermittent preventive treatment of malaria in pregnancy with mefloquine in hiv-infected women receiving cotrimoxazole prophylaxis: a multicenter randomized placebo-controlled trial Full Text PLoS Medicine, September 26, 2014   

 

14 Attitudes toward molecular testing for personalized cancer therapy Cancer, September 26, 2014

 

15 Surgical results of pelvic exenteration in the treatment of gynecologic cancer Full Text World Journal of Surgical Oncology, September 26, 2014  

 

16 Hyperandrogenism after menopause European Journal of Endocrinology, September 26, 2014

 

17 Osteocalcin is Higher Across Pregnancy in Caucasian Women with Gestational Diabetes Mellitus Canadian Journal of Diabetes, September 26, 2014

 

18 Molecular effects of lapatinib in patients with HER2 positive ductal carcinoma in situ Breast Cancer Research, September 26, 2014   

 

19 Hypertension risk in Dutch women with symptomatic uterine fibroids American Journal of Hypertension, September 26, 2014

 

20 Adherence to antiretroviral therapy during pregnancy and the first year postpartum among HIV-positive women in Ukraine Full Text BMC Public Health, September 26, 2014    

ارسال شده توسط دکتر محمد هزارخانی در ساعت 2:48 بعد از ظهر |
Fri 26 Sep 2014

Nature Genetics news Sep.26,2014

Frank Geller, Bjarke Feenstra, Lisbeth Carstensen, Tune H Pers, Iris A L M van Rooij, & Mads Melbye Nature Genetics46,957–963(2014)doi:10.1038/ng.3063/10 August 2014

Hypospadias is a common congenital condition in boys in which the urethra opens on the underside of the penis. We performed a genome-wide association study on 1,006 surgery-confirmed hypospadias cases and 5,486 controls from Denmark. After replication genotyping of an additional 1,972 cases and 1,812 controls from Denmark, the Netherlands and Sweden, 18 genomic regions showed independent association with P < 5 × 10−8.

Together, these loci explain 9% of the liability to developing this condition. Several of the identified regions harbor genes with key roles in embryonic development (including HOXA4, IRX5, IRX6 and EYA1). Subsequent pathway analysis with GRAIL and DEPICT provided additional insight into possible genetic mechanisms causing hypospadias.

ارسال شده توسط دکتر محمد هزارخانی در ساعت 8:46 قبل از ظهر |