Edited by:Mohammad  Hezarkhani  MD,Urologist

Board-Certified of Urology,Tehran  University ,The Member  of  Iranian  Urological  Association

Madaen Hospital  Tehran Iran

Mohammad.hezarkhani@yahoo.com

www.Hezarkhani.blogfa.com  hosted in Washington DC, United States

september,6 , 2013

Background: Location : 6p21.3

Sequence : Chromosome: 6; NC_000006.11 (32362513..32374900, complement)

GeneRIFs: Gene References Into Functions

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2.Upon stratification analysis in search for a synergistic effect in sarcoidosis given the extensive linkage disequilibrium between BTNL2 rs2076530_A and HLA-DRB1*08:03; the risk-bearing allele of these two loci interact negatively.

3.We unravel the role of unexplored immunologically important genes, BAT1 and BTNL2, and the haplotypes of the significantly associated SNPs therein, to understand susceptibility to the disease, leprosy and its differential severity.

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Rare, inherited mutations account for 5% to 10% of all prostate cancer cases. However, to date, few causative mutations have been identified.Results indicate that rare BTNL2 variants play a role in susceptibility to both familial and sporadic prostate cancer.

References:

1- Germline Missense Variants/ BTNL2 Gene/Associated with Prostate Cancer Susceptibility  

Liesel M. FitzGerald1, Akash Kumar2, Evan A. Boyle2, Yuzheng Zhang1,1, Suzanne Kolb1,

Marni Stott-Miller1, Tiffany Smith4, Danielle M. Karyadi4, Elaine A. Ostrander4Li Hsu1,

Jay Shendure2, and Janet L. Stanford1,3/Authors' Affiliations: 1Division of Public Health Sciences, Fred Hutchinson Cancer Research Center; 2Department of Genome Sciences, School of Medicine, 3Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington; and 4Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland  June 23, 2013. ©2013 American Association for Cancer Research.

2- National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA/August.21.2013