Curcumin and Prostate  Cancer  

         

پروتئین کیناز  D1 ، یک کینازچند کاره محسوب می شود که به حد وافری دربافت طبیعی پروستات بیان می گردد.کاهش بیان PKD1، با پیشروی سرطان پروستات همسو می باشد. بنابراین فرآوردهای طبیعی ویا صناعی که بتوانند این مسیرپیام رسانی را تنظیم کنند، بعنوان یک روش درمانی بدیع که قادراست ازاین بیماری جلوگیری کرده ویا درمان کند،محسوب خواهند شد.

 کورکومین، جزئی فعال اززردچوبه به حساب می آید که با مهار فعالیت رونویسی beta-cateninهسته ای وایجاد تغییراتی در beta-catenin signalingوافزایش مقادیرbeta-cateninغشایی درسلولهای سرطان پروستات، خواص ضد سرطانی خود را اعمال می کند.

 مدولاسیون وقایع سلولی یاد شده توسط کورکومین شامل موارد زیراست:

1-کاهش پرولیفراسیون سلولی

2-کاهش شکل گیری کولونی  سلولی

3-مهار حرکت پذیری سلولی ازطریق کاهش مقدارCofilinفعا ل

4-افزایش انباشتگی سلولهای سرطان پروستات

براساس مطالعاتی که اخیرا صورت پذیرفته، مصرف کورکومین همزمان با درمان محرومیت آندروژنی ، رشد تومور پروستات راکاهش می دهد. بعلاوه محققین معتقدند که کورکومین تا حدودی ازتبدیل شکل حساس به درمان هورمونی بیماری به فرم مقاوم به درمان هورمونی، جلوگیری می کند.

خاطرنشان می کنم که در هنگام برگشت بیماری، ما با پدیده دوباره فعا ل شدگی گیرنده آندروژنی روبروهستیم.گیرندههای هسته ای وعوامل پیشتاز شکل گیری وپیشروی بیماری راپیشبری می کنند.

درشکل مقاوم به درمان هورمونی، فعالیت احیا شده گیرنده آندروژنی وتنظیم افزایشی Coactivator protein 300وعوامل پیشتاز، ادامه درمان محرومیت آندروژنی ره به جایی نمی برد. پس هدف اصلی درحال حاضرمقابله با گیرنده ای است که بنحو لجام گسیخته ای فعال شده ومی بایست مهار گردد.

 کورکومین، فعال کنندههای گیرنده هسته ای موسوم به p300وپروتئین متصل به CREB-1را که با درمان محرومیت آندروژنی مقابله می کنند را، مهار می نماید.

 دکترKaren Knudsonازدانشگاه توماس جفرسون، با اضافه کردن کورکومین به محیط حاوی سلولهای سرطانی پروستات توانست چرخه سلولی رامهار کرده وازتکثیر آنها جلوگیری نماید. همین آزمایش برروی موشهای مبتلا به سرطان پروستات نیز انجام شد که اثری مشابه رادر پی داشت.

 References:

Curcumin Attenuates β-catenin Signaling in Prostate Cancer Cells through Activation of Protein Kinase D

   Vasudha Sundram,1 Subhash C. Chauhan,1,2 Mara Ebeling,1 and Meena Jaggi1,2,*

    PLoS One.    2012; 7(4): e35368. Published online 2012 April 16. doi:   

Curcumin  May Benefit Prostate Cancer Patients

    Natural  Standard:The Authority On Integrative Medicine      February   2012 

Benefit Of Curcumin  for Prostate Cancer

     Naturally  Health  Products    05/11/2012

 

عوامل خطرسازمسئول شروع سرطان پروستات:سن، موقعیت وعادتهای رفتاری

 

Michael F Leitzmann1 and Sabine Rohrmann2

1Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany

2Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland 

Clin Epidemiol. 2012; 4: 1–11.

2012 January 5. doi:  10.2147/CLEP.S16747

Copyright © 2012 Leitzmann and Rohrmann, publisher and licensee Dove Medical Press Ltd.

At present, only three risk factors for prostate cancer have been firmly established; these are all nonmodifiable: age, race, and a positive family history of prostate cancer. However, numerous modifiable factors have also been implicated in the development of prostate cancer.

 In the current review, we summarize the epidemiologic data for age, location, and selected behavioral factors in relation to the onset of prostate cancer. Although the available data are not entirely consistent, possible preventative behavioral factors include increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy.

Factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat. By comparison, alcohol probably exerts no important influence on prostate cancer development. Similarly, dietary supplements are unlikely to protect against the onset of prostate cancer in healthy men. Several factors, such as smoking and obesity, show a weak association with prostate cancer incidence but a positive relation with prostate cancer mortality. Other factors, such as fish intake, also appear to be unassociated with incident prostate cancer but show an inverse relation with fatal prostate cancer.

 Such heterogeneity in the relationship between behavioral factors and nonadvanced, advanced, or fatal prostate cancers helps shed light on the carcinogenetic process because it discerns the impact of exposure on early and late stages of prostate cancer development. Inconsistent associations between behavioral factors and prostate cancer risk seen in previous studies may in part be due to uncontrolled detection bias because of current widespread use of prostate-specific antigen testing for prostate cancer, and the possibility that certain behavioral factors are systematically related to the likelihood of undergoing screening examinations. In addition, several genes may modify the study results, but data concerning specific gene–environment interactions are currently sparse.

 Despite large improvements in our understanding of prostate cancer risk factors in the past two decades, present knowledge does not allow definitive recommendations for specific preventative behavioral interventions. 

Researchers find possible link between jumping genes and cancerous tumor growth

 

Researchers find possible link between jumping genes and cancerous tumor growth

Journal reference: Science

June 29, 2012

محققین دانشگاه هاروارد وبیمارستان زنان بریگهام، به شواهد قابل قبولی دست یافتند که درطی آن، تغییررتروترانسپوزون(یک دسته ازعناصر ژنتیکی جهنده،نظیرترانسپوزونها می باشند که توسط ویروسهای RNAدار ویا RNAمتحرک منتقل می شوند. رتروپوزونها، reverse transcriptaseرا به رمزدرآورده وباعث تولید DNAمکملازرویmRNAشده ودی ان ای ساخته شده وارد کروموزوم میزبان شده وبخشی ازژنوم سلول میزبان را تشکیل می دهد) درسلولهای سوماتیکی، مسئول رشد بعضی ازانواع تومورهای سرطانی میباشد.

ژنهای جهنده(Jumping genes) درگونه های وسیعی ازگیاهان وجانوران یافت شده، ولی درپستانداران ،منجمله انسان، بندرت دیده می شود. این ژنها درفرآیندهای تکاملی دخالت داشته وبا ایجاد جهشهایی دراین موجودات، تغییرات لازم جهت رشدوتکامل رافراهم می آورند.

محققین متوجه شدند که عناصر لازم برای ژنهای جهنده درپستانداران ومنجمله انسان وجود دارد، ولی درشرایط فیزیولوژی، منع شده هستند.

درطی تحقیق جدید، با استفاده ازنرم افزارکامپیوتری ازنوع روش محاسباتی موسوم به Tea، به بررسی عنصرقابل ترانسپوزون(قطعه مجزایی ازمولکول DNAمی یاشد که می تواند خود را درجایگاههای مختلفی ازDNAیک سلول داخل نماید.این قطعه ازDNAحاوی اطلاعات لازم جهت ساخت پروتئینهای ضروری جهت عمل انتقال خود است.

انتهاهای یک ترانسپوزون معمولا یکسان بوده اما درقیاس با یکدیگردرجهت معکوس قرارگرفته اند.وارد شدن یک ترانسپوزون درمحل جدید منجر به ایجاد تکرارمستقیم سه تا یازده جفت باز درمولکول DNAهدف می شود)درتومورهای پروستات،تخمدان،میلوم مولتیپل،کولورکتال ومغزپرداخته شد.

درتمام تومورهای فوق بجزمغزو میلوم، ژنهای جهنده نسبت به بافت طبیعی بیشترمشاهده شد. انتظار می رودکه این ژنها درروند رشد بعضی ازتومورها دخالت داشته باشند.

دراین تحقیق مشخص شدکه، Transposable element insertionsدرتومورهای مختلف متنوع بوده وشرایط محیطی رابرای رشد تومورفراهم می آورند.

میزان صحت این نرم افزارمحاسباتی، حدود97% می یاشد، هرچند که گاهی ممکن است دراثرتکرارشدگی ژنهایی که درجواریکدیگرهستند، اشتباهاتی بوقوع بپیوندد.

 

Vascular endothelial growth factor A, secreted in response to transforming growth factor-β1 under hy

Eric Darrington*, Miao Zhong*, Bao-Han Vo and Shafiq A Khan*Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA

18 June 2012

درتعدادی ازبیماریهای بدخیم، هیپوکسی وعامل رشد ترانسفورمینگ بتا- یک، بیان عامل تیپ یک رشد اندوتلیوم عروقی را اقزایش می دهند. همسویی این دوعامل می تواند درپیشروی و متاستاز سرطان پروستات پیشرفته موثر باشد.

ما دریافتیم که، TGF/beta 1، تولید VEGFA1را درسلولهای طبیعی وبدخیم(PC3) القا کرده وهیپوکسی فقط دررده سلولهای سرطانی پروستات چنین اثری رااعما ل می نماید.

بطورکلی درخلال بیماری سرطان پروستات، هیپوکسی ، بیان VEGFAرادرسلولهای بدخیم افزایش می دهد. یادآوری می کنم که پیام اتوکرینی ناشی ازVEGFAالزاما درروند پیشرفت وایجاد متاستازدخالت موثری دارد.

فعالیت VEGFAازطریق گیرندههای خاص آن یعنی FLt-1وFLk-1/KDR به انجام می رسد. درحالیکه

VEGFA-1mRNAفقط درسلولهای طبیعی اپی تلیالی پروستات شناسایی شد، VEGFA-2mRNAوVEGFA protein درسلولهای رده pc3بیان شده بود.

تجویزVEGFA 165،سبب فسفوریلاسیون کینازخارج سلولی ERK1/2دررده سلولهای PC3می شود، وبنابراین این فکربه ذهن متبادر می شود که، عملکرد اتوکرینی VEGFA خاص سرطان پروستات می باشد.

نکته مهم این است که، فعال شدن VEGFR-2توسط VEGFA165، قدرت جابجایی سلولهای سرطانیPC3را افزایش می دهد. همین اثراز طریق VEGFAآندوژن که، باتحریک TGF/BETA1وهیپوکسی تولید می گردد،نیزمشاهده شده است.

این یافته ها مبین آن است که لوپ اتوکرینی-VEGFA via  VEGFR/2   - برای اثرات تومورزایی حاصل از هیپوکسی وtgf/beta-1 درخلال سرطانهای متاستاتیک پروستات، نقش حیاتی را ایفا می کند.

دانش ارولوژی 2012

 

معرفی یک بیمار،تظاهرانکوسیتوم آدرنال به فرم سندروم کوشینگ

 Case report and literature review

Urological Science (December 2011), 22 (4), pg. 166-168

Yung-Shu Lee; Wun-Rong Lin; Chi-Kuan Chen; Yi-Wei Pai; Marcelo Chen

Abstract Adrenocortical oncocytomas are very rare, with only 47 cases reported in the English literature. They are usually benign and nonfunctional. Herein, we report on a 30-year-old female patient presenting with extreme weight gain (17 kg in a year), moon face, buffalo hump, ...

Adrenocortical oncocytomas are very rare, with only 47 cases reported in the English literature. They are usually benign and nonfunctional.

Herein, we report on a 30-year-old female patient presenting with extreme weight gain (17 kg in a year), moon face, buffalo hump, central obesity and edema in both legs. Computed tomography revealed a 3.2 cm solid left adrenal tumor. A clipless laparoscopic adrenalectomy was performed. Pathology revealed an adrenocortical oncocytoma.

بروزسیستیت آمفیزماتو بعد ازجراحی سنگ مجرای صفراوی 

 Urological Science (December 2011), 22 (4), pg. 163-165

Sheng-Hsuan Chen; Hui-Ming Chung; Tser-Min Wu

Abstract Emphysematous cystitis (EC) is a potentially fatal disease if treatment is delayed. A high index of suspicion is crucial for an early diagnosis of the disorder, which typically occurs in patients with poorly controlled diabetes. Although gas in the bladder is suggestive of EC, other differential... [view more]

Emphysematous cystitis (EC) is a potentially fatal disease if treatment is delayed. A high index of suspicion is crucial for an early diagnosis of the disorder, which typically occurs in patients with poorly controlled diabetes. Although gas in the bladder is suggestive of EC, other differential diagnoses include a postoperative state, an enterovesical fistula and urological instrumentation.

We report on a 73-year-old female diabetic patient who had undergone major surgery for an obstructive common bile duct stone 3 weeks prior to the onset of EC. She presented with an initial picture of severe sepsis, possibly due to a postoperative infection of the urinary and/or biliary tract.

She responded well to prompt therapy with antibiotics, adequate drainage of the urinary and biliary tracts, and good glycemic control. She was discharged on hospital day 7 and remained stable during the 3-month follow-up period. 

بروزهرنی اینگوئینال بعد ازپروستاتکتومی رادیکال

Urological Science (March 2012), 23 (1), pg. 1-4

Jungle Chi-Hsiang Wu; Yen-Chuan Ou

Abstract Since prostate-specific antigen (PSA) screening began in the 1980s in Taiwan, there has been a significant increase in the detection of prostate cancers (PCs) at an earlier stage. For clinically localized PC, a radical prostatectomy (RP) remains the gold standard treatment. However, ... [view more]

Since prostate-specific antigen (PSA) screening began in the 1980s in Taiwan, there has been a significant increase in the detection of prostate cancers (PCs) at an earlier stage. For clinically localized PC, a radical prostatectomy (RP) remains the gold standard treatment. However, patients undergoing a RP for PC are at risk of onset or worsening of inguinal hernias (IHs). We reviewed the current status of IHs after a RP. We reviewed literature published from PubMed using the key words of “inguinal hernia”, “prostatectomy”, and “prostate cancer”. The postprostatectomy mechanism was illustrated. The incidences of various prostatectomies were recorded. The prediction and prevention of postprostatectomy IHs were analyzed.

 Disruption of the transversalis fascia caused by surgical procedures was proposed as contributing to postprostatectomy-related IH formation because it assaults the anatomic-physiological balance in the abdominal wall. The myopectineal orifice is traversed by the spermatic cord and femoral vessels, and its inner surface is sealed by the transversalis fascia.

 A body mass index of <23 kg/m2 and a history of previous IH repair were significant risk factors for postoperative IH. The incidence of IHs after surgery was reported to range from 12.4% to 23.9%, and most IHs occur within 6–24 months postprostatectomy. The incidence of IHs is greater with the extraperitoneal approach than with the transperitoneal approach. A preoperative abdominal computed tomography (CT)-scan might identify asymptomatic IHs, but the test lacks sensitivity and is inferior to a simple physical examination (PE). A PE of the groin should be performed before a RP, and careful surgical manipulation is essential to prevent postoperative IHs. The concurrent repair of any detectable IHs at the time of a prostatectomy could significantly reduce the incidence of postoperative IHs.

همزمانی هرنی اینگوئینال با عفونت انگلی

 A case report and literature review

Urological Science (March 2012), 23 (1), pg. 26-27

Cheng-Che Wu; Wen-Shan Liao; Min-Shin Kao; Shih-Chieh Huang; Biing-Yir Shen

Abstract Inguinal hernia repair is a common and straightforward surgical procedure. Case reports of postsurgical incidental parasitic infections are very rare. A 72-year-old male presented at our hospital with a swollen mass in the right groin area and underwent right inguinal hernia repair. Unexpectedly, parasitic ova... [view more]

Abstract

Inguinal hernia repair is a common and straightforward surgical procedure. Case reports of postsurgical incidental parasitic infections are very rare. A 72-year-old male presented at our hospital with a swollen mass in the right groin area and underwent right inguinal hernia repair. Unexpectedly, parasitic ova were discovered in the hernial sac. This report describes this rare case, in addition to a review of the literature.


بروز همزمان سرطان اولیه معده وکارسینوم کلیه 

 A case report and literatures review

Urological Science (March 2012), 23 (1), pg. 28-30

Kung-Ning Hu; Wei-Hong Lai; Po-Tsang Tseng; Wen-Ching Wang; Kun-Hung Shen

 

Abstract A 73-year-old woman was admitted and treated because of epigastric fullness, palpitation, and tarry stool for 2 days. Gastric cancer was found via panendoscopy. A preoperative abdominal computed tomographic scan revealed a hypervascular mass in the left kidney; renal cell carcinoma (RCC) was ...  

A 73-year-old woman was admitted and treated because of epigastric fullness, palpitation, and tarry stool for 2 days. Gastric cancer was found via panendoscopy.

 A preoperative abdominal computed tomographic scan revealed a hypervascular mass in the left kidney; renal cell carcinoma (RCC) was the initial impression. A concomitant surgery for subtotal gastrectomy and radical left nephrectomy was performed. The pathological examination confirmed gastric adenocarcinoma (T2a) and RCC (T2b). Convalescence was uneventful and she was discharged in stable condition. There was no evidence of tumor recurrence at a 20-month follow-up examination.

Elderly people with early gastric cancers have a relative higher probability of developing a synchronous tumor than younger people. The incidence of synchronous gastric cancer and RCC is quite low, and concomitant surgery is rare. Surgeons need to be aware of the possibility of a synchronous second primary cancer when the initial gastric cancer is diagnosed.

A concomitant surgery for gastrectomy and radical nephrectomy can be safely performed in selected patients, which can achieve feasible oncological control.

 

Flavonoid Ampelopsin Inhibits the Growth and Metastasis of Prostate Cancer In Vitro and in Mice

Feng Ni1,2, Yi Gong2, Linglin Li2, Hamid M. Abdolmaleky2, Jin-Rong Zhou2*

Department of Pharmaceuticals, Fujian Health College, Fuzhou, Fujian, People's Republic of China, Nutrition/Metabolism Laboratory, Department of Surgery, Beth Israel-Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

مقصود ازاین مطالعه، بررسی اثرات آمپلوپسین (دی هیدرومیریستین، یک فلاونول می باشد که ازدرخت کشمش ژاپنی موسوم به Hovenia dulcisبدست آمده) برروی رشد ومتاستازسرطان پروستات می باشد.

آمپلوپسین، با القای آپوپتوز،مانع پرولیفراسیون سلولهای سرطانی حساس به آندروژن وتا حدی سلولهای مقاوم به فقرآندروژنی، می گردد.in vitro این اثر برروی سلولهای سالم پروستات بسیار کم می باشد.

این فلاونول درمحیط آزمایشگاه و از طریق سرکوب بیان ژن CXCR4ازتوان مهاجرتی وتهاجمی سلولهای سرطانی رده pc-3 پروستات می کاهد.

تجویزآمپلوپسین، 300 میلی گرم برحسب هرکیلوگرم وزن بدن به موشهای مبتلا به سرطان پروستات، 49.2% ازوزن تومور ، تا 54.5% ازمتاستاز لنفی و93% ازمتاستاز ریوی کاست، بدون اینکه وضعیت تغذیه ویا وزن آنها دستخوش تغییری گردد.

نتیجه:اثرات آمپلوپسین

1-کاهش قدرت پرولیفراسیون سلولهای سرطان پروستات

2-کاهش روند آنژیوژنز

3-کاستن ازبیان CXCR4 

 

Published: June 5, 2012

Edited by:Mohammad  Hezarkhani MD,Urologist

Certified Board from  Tehran University  1/July/2012

معرفی یک بیمار:عفونتهای مکرر ادراری ناشی ازدیورتیکولیت بدون علامت کولون

 

Evangelos Falidas,1 Georgios Anyfantakis,2 Stavros Boutzouvis,1 Michail Kyriakopoulos,3 Stavros Mathioulakis,1 Konstantinos Vlachos,1 and Constantinos Villias1

11st Department of Surgery, 417 NIMTS Veterans Hospital of Athens, Athens 11521, Greece
2Department of Radiology, 417 NIMTS Veterans Hospital of Athens, Athens 11521, Greece
3Department of Urology, 417 NIMTS Veterans Hospital of Athens, Athens 11521, Greece

Accepted 11 November 2011

A 75-year-old man came to the emergency department complaining of high fever of 4-day duration and urgency in urination. He mentioned recurrent and multiple (five) episodes of urinary tract infections over the last 3 months attributed to a recent (12 months ago) transurethral prostatectomy. These episodes were resolved with oral administration of various antibiotics.

Escherichia coli was constantly found in urine cultures. However, no history of abdominal pain, fever, particular changes of defecation habits, pneumaturia, or fecaluria was referred. No diverticulosis or diverticulitis was identified in prior medical examinations. Repeated urinary tract ultrasound controls were undertaken in order to exclude prostate, urinary blabber, uretere, or kidneys abnormalities or lithiasis without particular abnormal findings. On admission, leukocytosis (17000 mm3) was the unique abnormal laboratory finding. Pyuria and hematuria were found in urinalysis. Upon palpation, no abdominal pain or positive Giordano maneuver were observed. Urine and blood cultures were taken. He received intravenously fluids and empirical wide spectrum antibiotic treatment (ciprofloxacin). Temperature was completely normalized 2 days later. Urine cultures revealed Escherichia coli and Pseudomonas aeruginosa (colony-forming units (CFU) >106/mL of urine) sensitive to ciprofloxacin. No atypical antibiotic sensitivities or resistances were observed according to the microbiologic data of our hospital.

Cystoscopy demonstrated redness of the lateral wall of the bladder without any fistula identified. Cystography also did not demonstrate any fistula tract. However, abdominal computed tomography scan (CT) revealed the presence of free air within the urinary bladder in contact with perisigmoid thickening and colon diverticula .

In addition, colonoscopy was performed in order to exclude colonic neoplasm. No neoplasm was identified; however, diffuse diverticula of the sigmoid colon with thickness, edema, and inflammation into the lumen were observed. No evident fistula tract was revealed.

Colovesical fistula is a common complication of diverticulitis. Pneumaturia, fecaluria, urinary tract infections, abdominal pain, and dysuria are commonly reported. The authors report a case of colovesical fistula due to asymptomatic diverticulitis, and they emphasize the importance of deeply investigate recurrent urinary tract infection without any bowel symptoms.

Urology/Neurosurgery/Ob.Gy/Otolaryngology/Dermatology and

Dermatology Update 2012

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Boosting blood system protein complex protects against radiation toxicity

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Cold-air anesthesia reduces pain of laser treatment

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Diseases, Conditions, Syndromes Jun 22, 2012

Many psoriasis patients undertreated for CV risk factors

A large proportion of patients with moderate-to-severe plaque psoriasis are underdiagnosed and undertreated for cardiovascular (CV) risk factors, according to a study published in the July issue ...

Diseases, Conditions, Syndromes Jun 22, 2012

Accuracy of melanoma detection up in specialized clinics

From 1998 to 2007, the accuracy of melanoma detection improved in specialized but not non-specialized clinical settings, according to research published in the July issue of the Journal of th ...

Cancer Jun 21, 2012

Study suggests link between smoking, increased risk of cutaneous squamous cell carcinoma

Smoking appears to be associated with an increased risk of cutaneous squamous cell carcinoma skin cancer, according to a report of a meta-analysis and review of available medical literature published Online First by Archives of ...

Cancer Jun 18, 2012

Psoriasis tied to 14 other autoimmune diseases

Patients with psoriasis have significantly higher odds for having at least one of 14 other autoimmune diseases, according to a study published online June 4 in the Journal of the American Ac ...

Immunology Jun 15, 2012

New peri-op approach accurately IDs melanoma in nail matrix

Intraoperative reflectance confocal microscopy (RCM) can be used to diagnose melanonychia striata in the nail matrix, according to a study published online June 7 in the British Journal of De ...

Cancer Jun 14, 2012

Head lice beginning to show permethrin resistance

Although live head lice obtained from school-aged children in Paris remain susceptible to the insecticide malathion, approximately 14 percent have been found to be resistant to permethrin, suggesting ...

Diseases, Conditions, Syndromes Jun 05, 2012

Slow-growing melanomas lose structure, vary color with time

The diameter of most slow-growing melanomas (SGMs) changes very little over time, but the lesions can become more disorganized, less structured, and change or develop new colors, according to ...

Cancer Jun 01, 2012

Skin cell transplant may offer new hope to vitiligo patients

Skin cell transplants can restore pigment to the skin of some patients with the disorder known as vitiligo, new research finds.

Diseases, Conditions, Syndromes Jun 22, 2012

Protein may be key to psoriasis and wound care

Psoriasis is an autoimmune disorder in which skin cells proliferate out of control. For some hard-to-heal wounds, the problem is just the opposite: Restorative skin cells don't grow well or fast enough. In a paper published ...

Immunology Jun 21, 2012

Indoor tanners rationalize risky behavior, study finds

Young people who use tanning beds rationalize the risky behavior with statements like "everything causes cancer these days," a new study finds.

Health Jun 20, 2012

Double the pain: Biologists find the cause of pain in the treatment of fair skin cancer

Apply the ointment, light on, light off – that's how easy it is to cure various forms of non-melanoma skin cancer. However, the majority of patients suffer severe pain during the so-termed photodynamic ...

Medical research Jun 20, 2012

 Endocrinology Update 2012

Women are more prone to hypoglycaemia than men

Just how important a gender-specific perspective and the personalised treatment of illnesses are between men and women is being demonstrated by two current studies at the MedUni Vienna, which are being led ...

Diseases, Conditions, Syndromes Jun 27, 2012

Aspirin may not prevent blood clots that cause heart attacks and strokes among diabetics

Many patients with type 2 diabetes may be aspirin resistant. That means the standard aspirin dose may not protect them against blood clots that cause heart attacks and strokes among diabetics, a new clinical study finds. ...

Diabetes Jun 25, 2012 | not rated yet | 0

BPA exposure in pregnant mice changes gene expression of female offspring

Prenatal exposure to bisphenol A, or BPA, a chemical found in many common plastic household items, can cause numerous genes in the uterus to respond differently to estrogen in adulthood, according to a study using a mouse ...

Health Jun 26, 2012 

Eat slowly and reduce diabetes risk

Your parents must have told you a thousand times - don't eat so fast, slow down! Now it appears that scientific research is backing them up. At the recent joint International Congress of Endocrinology and European Congress ...

Diabetes Jun 25, 2012

Investigational hormone replacement promising treatment for rare disorder

An investigational parathyroid hormone replacement effectively treated a rare disorder characterized by low calcium and high phosphate levels in the blood, a new study finds. The results will be presented at The Endocrine ...

Health Jun 25, 2012

Fungicide used on farm crops linked to insulin resistance

A fungicide used on farm crops can induce insulin resistance, a new tissue-culture study finds, providing another piece of evidence linking environmental pollutants to diabetes. The results will be presented at The Endocrine ...

Diabetes Jun 25, 2012

Liraglutide with insulin improves poorly controlled Type 1 diabetes

Obese adults with poorly controlled Type 1 diabetes can better control their blood sugar by adding liraglutide, a Type 2 diabetes drug, to their insulin therapy, a new study finds. The results, which will be presented at ...

Diabetes Jun 25, 2012

Physical fitness may improve survival among diabetes patients with heart dysfunction

Being physically fit may improve survival rates among diabetes patients with a particular type of heart abnormality, a new study determines. The results will be presented at The Endocrine Society's 94th Annual Meeting in ...

Diabetes Jun 25, 2012

Gene expression test identifies low-risk thyroid nodules

A new test can be used to identify low-risk thyroid nodules, reducing unnecessary surgeries for people with thyroid nodules that have indeterminate results after biopsy. The results of the multi-center trial, which includes ...

Surgery Jun 25, 2012

Vitamin D deficiency common among adolescents evaluated for weight-loss surgery

Most adolescents preparing for weight-loss, or bariatric, surgery are deficient in vitamin D, a new study demonstrates. The results to be presented at The Endocrine Society's 94th Annual Meeting in Houston.

Health Jun 25, 2012

Experts recommend men at risk for osteoporosis undergo bone density testing

Osteoporosis in men causes significant morbidity and mortality. Today, the Endocrine Society released clinical practice guidelines (CPG) for management of this condition in men. "Osteoporosis in Men: An Endocrine Society ...

Diseases, Conditions, Syndromes Jun 18, 2012

Vitamin D with calcium shown to reduce mortality in elderly

A study recently published in the Endocrine Society's Journal of Clinical Endocrinology and Metabolism (JCEM) suggests that vitamin D—when taken with calcium—can reduce the rate of mortality in seniors, therefore provid ...

Health Jun 15, 2012

Physical activity reduces compensatory weight gain after liposuction

Abdominal liposuction triggers a compensatory increase in visceral fat, which is correlated with cardiovascular disease, but this effect can be counteracted by physical activity, according to a recent study in the Journal of ...

Other Jun 13, 2012

 

Urology/Neurosurgery/Ob.Gy/Otolaryngology/Dermatology and

Edited by:Mohammad  Hezarkhani MD,Urologist

Certified Board from Tehran Univaersity   30/June/2012

Statin Use and Risk of Prostate Cancer Recurrence in Men Treated With Radiation Therapy

June 26th, 2012 Posted in prostate cancer risks

There has been growing interest in the potential anticancer activity of statins based on preclinical evidence of their antiproliferative, proapoptotic, and radiosensitizing properties. The primary objective of a new study was to determine whether statin use is associated with improved clinical outcomes in patients treated with radiotherapy (RT) for prostate cancer.

The study team has concluded statin use was associated with a significant improvement in FFBF, FFADT, and RFS in this cohort of men treated with RT for prostate cancer. The favorable effect of statins may be mediated by direct effect or via the LDL-lowering effect of these medications.

 Aspirin Use May Increase Prostate Cancer Risk

June 29, 2012

BANFF, Alberta—Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with an increased likelihood of having prostate cancer (PCa) found on prostate biopsy, according to data presented at the Canadian Urological Association annual meeting.

Bimal Bhindi, MD, and colleagues at the University of Toronto studied 931 men undergoing prostate biopsy. Patients taking aspirin and other NSAIDs had a significantly higher rate of biopsy-detected PCa than those taking no NSAIDs (65% vs. 42%). After adjusting for multiple variables, use of aspirin and other NSAIDs was associated with a significant twofold and threefold higher odds of PCa detection, respectively, compared with no NSAID use. Additionally, use of aspirin, but not other NSAIDs, was associated with a significant 64% increased odds of having high-grade PCa detected compared with no NSAID use.

Testosterone-replacement therapy improves symptoms of metabolic syndrome

Hormone-replacement therapy significantly improved symptoms of metabolic syndrome associated with testosterone deficiency in men, a new study from Germany finds. The results to be presented at The Endocrine Society's 94th ...

Medications Jun 25, 2012

Similar outcomes for robot-aided, conventional nephrectomy

Robot-assisted and conventional laparoscopic partial nephrectomies have similar outcomes and complication rates, according to a study published in the July issue of The Journal of Urology.

Other Jun 22, 2012

New drugs, new ways to target androgens in prostate cancer therapy

Prostate cancer cells require androgens including testosterone to grow. A recent review in the British Journal of Urology International describes new classes of drugs that target androgens in novel ways, providing altern ...

Cancer Jun 20, 2012

Risk of calcium oxalate stones not affected by oxalate intake

Eating large amounts of oxalate does not significantly affect the risk of developing calcium oxalate stones if the recommended amount of dietary calcium is also eaten, according to a study published ...

Diseases, Conditions, Syndromes Jun 06, 2012

Capability of curry component to treat disease merits US patent

A U.S patent issued today to the University of Rochester and two other entities for the use of compounds related to a popular spice in the fight against cancer, acne, baldness, and other medical conditions.

Medical research Jun 12, 2012

Intravesical chondroitin sulfate of little benefit in cystitis

Intravesical sodium chondroitin sulfate is not recommended for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) in women as it produces only minor improvements in symptoms ...

Diseases, Conditions, Syndromes Jun 06, 2012

Gender, BMI impact bladder perforation during resection

For patients with bladder tumors, female gender, low body mass index, and tumor characteristics correlate with the risk of bladder perforation during transurethral resection, according to research ...

Diseases, Conditions, Syndromes Apr 17, 2012

New prostate cancer screening guidelines face a tough sell, study suggests

Recent recommendations from the U.S. Preventive Services Task Force (USPSTF) advising elimination of routine prostate-specific antigen (PSA) screening for prostate cancer in healthy men are likely to encounter ...

Cancer May 25, 2012

Robotic-assisted prostate cancer surgery drives up costs

In one of the most comprehensive analyses to date of the cost of robotic-assisted, laparoscopic surgery for prostate cancer, researchers at UPMC found that this now-dominant surgical approach is significantly more costly ...

Cancer May 23, 2012

Prevalence of kidney stones doubles in wake of obesity epidemic

The number of Americans suffering from kidney stones between 2007 and 2010 nearly doubled since 1994, according to a study by researchers at the University of California, Los Angeles (UCLA) and RAND.

Diseases, Conditions, Syndromes May 23, 2012

Recommendation against PSA test too drastic: WU expert

A new recommendation issued today by the U.S. Preventive Services Task Force against routine PSA testing for healthy men age 50 and older goes too far, says a prostate cancer expert at the Siteman Cancer ...

Cancer May 22, 2012

Do bald men face higher risk of prostate cancer?

Got hair? If you don't, you might have a higher risk of prostate cancer, a preliminary study suggests.

Cancer May 22, 2012