Severe Acne May Boost Prostate Cancer Risk
Severe Acne May Boost Prostate Cancer Risk
Renal & Urology News
December 11, 2017
Recent research suggests that P. acnes, which is associated with acne vulgaris, is more likely to be present in the prostatic tissue of patients with the disease than in healthy individuals
Severe acne in adolescence may greatly increase an individual's risk of prostate cancer later in life, according to research published in the International Journal of Cancer.
The etiology of prostate cancer is poorly understood, though recent research suggests that Propionibacterium acnes, which is associated with acne vulgaris, is more likely to be present in the prostatic tissue of patients with the disease than in healthy individuals.
For this prospective population-based study, researchers reviewed the data of 284,198 males born between 1952 and 1956. Nearly all (more than 99% of) included individuals underwent conscription examinations in the 1970s; most individuals were examined at 18 or 19 years old. After excluding individuals with another primary malignancy prior to prostate cancer, missing data, or errors in health information, 243,187 were included in the analysis.
The median follow-up was 36.7 years, during which 1633 men were diagnosed with prostate cancer. After adjusting for birth year, household crowding, and body mass index, among other factors, the authors calculated a hazard ratio (HR) for prostate cancer of 1.43 among those with acne in adolescence, with a higher HR for advanced disease (HR, 2.37).
Reference
Ugge H, Udumyan R, Carlsson J, et al. Acne in late adolescence and risk of prostate cancer. Int J Cancer. 2017 Dec 4. doi: 10.1002/ijc.31192
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